Cardio week 3 hypertension day 1

Hydrochlorothiazide mechanism of action

• Inhibits water reabsorption in the collecting duct.
• Stimulates calcium excretion in the loop of Henle.
• Inhibits sodium reabsorption in the distal convoluted tubule.
• Inhibits sodium reabsorption in the proximal convoluted tubule

What is the effect of hydrochlorothiazide on blood volume and blood pressure

• increase BV, Decrease BP

• Increase BV, Increase BP

• Decrease BV, Decrease BP

• No effect on BV, decrease BP

Increased excretion of Na+, Cl-, and K+ resulting in hyperpolarization of smooth muscle cells, ultimately resulting in vasodilation is the effect of what medication

• Potassium-sparing diuretics (e.g., spironolactone)
• ACE inhibitors (e.g., lisinopril)
• Thiazide diuretics (e.g., hydrochlorothiazide)
• Loop diuretics (e.g., furosemide)

Which of the following is NOT a thiazide or thiazide-like site III diuretics

• acetazolamide

• chlorthalidone

• metolazone

• indapamide

• hydrochlorothiazide

First line treatment of mild-moderate hypertension due to longer duration and smoother BP control

• ACE inhibitors
• Beta-blockers
• Calcium channel blockers
• Thiazide diuretics

_____ and K-sparing diuretics lose their effect when CrCl is less than 30-50 mL/min

• Thiazide diuretics
• Osmotic diuretics
• Carbonic anhydrase inhibitors
• Loop diuretics

_______ inhibit the Na/K/2Cl co-transporter (NKCC2) in the ascending loop of Henle, resulting in significant excretion of Na+, Cl-, and water

• Thiazide diuretics
• Potassium-sparing diuretics
• Carbonic anhydrase inhibitors
• Loop diuretics

Accumulation of furosemide in patients with lowered kidney function result in ototoxicity from _______ medication

• Acetazolamide

• Loop diuretics

• Thiazide and thiazide-like diuretics

• K-sparing diuretics

• Osmotic diuretics

Furosemide and torsemide are both what type of diuretics

• loop diuretics
• osmotic diuretics
• potassium-sparing diuretics
• thiazide diuretics

MOA of _______: act on the collecting ducts and either block aldosterone receptors or inhibit sodium channels

• Carbonic anhydrase inhibitors
• Potassium-sparing diuretics
• Loop diuretics
• Thiazide diuretics
• Angiotensin converting enzyme inhibitors (ACEIs)