PODA II: Final 1 chemistry

What are digitoxin and digoxin classified as?

• Cardenolides

• Catecholamines

• Alkaloids

• Steroids

Which compound is more hydrophilic, digitoxin or digoxin?

• Digitoxin

• Digoxin

What type of ring does digitoxin possess?

• A five-membered, alpha, beta-unsaturated lactone ring

• A six-membered, alpha, beta-unsaturated lactone ring

• A five-membered, alpha, beta-saturated lactone ring

• A six-membered, alpha, beta-saturated lactone ring

What is the composition of digitoxin?

• Aglycone digitoxigenin connected to three digitoxose sugar molecules

• Aglycone digitoxigenin connected to two digitoxose sugar molecules

• Aglycone digitoxigenin connected to one digitoxose sugar molecule

• Aglycone digitoxigenin connected to four digitoxose sugar molecules

What process produces digitoxin?

• Partial hydrolysis of the glucose molecule and acetate group from lanatoside A

• Complete hydrolysis of the glucose molecule and acetate group from lanatoside A

• Partial hydrolysis of the glucose molecule from lanatoside A

• Complete hydrolysis of the acetate group from lanatoside A

Which compound has a longer half-life, digitoxin or digoxin?

• Digitoxin

• Digoxin

How are digoxin and digitoxin eliminated from the body?

• Digoxin is primarily eliminated unchanged by renal tubule excretion, and digitoxin is extensively metabolized by the liver.

• Digoxin is primarily eliminated unchanged by liver metabolism, and digitoxin is extensively metabolized by the renal tubule excretion.

• Both digoxin and digitoxin are primarily eliminated unchanged by renal tubule excretion.

• Both digoxin and digitoxin are extensively metabolized by the liver.

What enzyme does digoxin inhibit?

• Na+K+ATPase

• PDE3

• CYP2C9

• Transamidase

How does quinidine affect digoxin's plasma concentration?

• It does not affect the concentration

• It increases the concentration to toxic levels by competitively binding to P-gp in the renal tubule

• It decreases the concentration by competitively binding to P-gp

• It increases the concentration by inhibiting P-gp-mediated secretion

How does verapamil affect the intestinal secretion of digoxin?

• It increases secretion by inducing P-gp expression

• It decreases secretion by inhibiting intestinal P-gp efflux

• It does not affect secretion

• It increases secretion by activating P-gp