Medicinal Chemistry Review

In animal studies, the therapeutic index is...

• .....the lethal dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.

• ....the minimum effective dose for 50% of the population divided by the lethal dose of a drug for 50% of the population. 

• .....the toxic dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.

• .....the lethal dose of a drug for 50% of the population divided by the minimum toxic dose for 50% of the population.

The therapeutic window is the...

• ....range of dosages between the minimum amounts of the drug that produce a toxic effect effect and a medically unacceptable adverse effect 

• ....range of dosages between the minimum amounts of the drug that produce an undesired effect and a medically unacceptable adverse effect 

• ....range of dosages between the minimum amounts of the drug that produce the desired effect and a medically unacceptable adverse effect 

• ....range of dosages between the minimum amounts of the drug that produce the desired effect and the toxic dose. 

Bioavailability is the ...

• .....fraction of the administered dosage that reaches the blood-brain barrier.

• .....how much of the drug is available.

• .....fraction of the administered dosage that reaches the target part of the human body 

• .....fraction of the administered dosage that reaches the target part of a plant.

Aspirin is prepared from

• sandalwood acid

• carboxylic acids

• ethanoyl chloride

• salicylic acid 

Penicillins are antibiotics produced

• ...by viruses

• ...by fungi 

• ...by e-coli

• ...by water borne creatures

Which of the following penicillins is likely to be the most soluble?

• penicillin G

• penicillin v

• Ampicillin

• Amoxicillin

Which functional group does penicillin NOT have.

• alkene

• carbonyl

• carboxylic acid

• amine

A natural source of opiates is...

Which opiate has the highest strength

• codeine

• morphine

• diamorphine

• opium

Aspirin has a ............................ effect with alcohol.