Medicinal Chem - D.4/D.6

What is the normal pH range of the stomach?

• 4-6

• 1-3

• 3-5

• 0-2

What type of cells in the stomach secrete hydrochloric acid?

• G cells

• Chief cells

• Parietal cells

• Mucous cells

Which of the following is an example of an antacid?

• Omeprazole

• Cimetidine

• Ranitidine

• Magnesium hydroxide

How do antacids counteract stomach acid?

• By blocking the action of histamine

• By inhibiting the production of acid in the stomach

• By neutralizing the acid in the stomach

• By increasing the secretion of mucus in the stomach

Which of the following solvents is NOT polar?

• Methanol

• Toluene (methylbenzene)

• Water

• Ethanol

What percentage of the initial mass in a given reaction to synthesize medicines is accounted for by solvents?

• 10-20%

• 20-30%

• 50-60%

• 80-90%

How are polar solvents typically disposed of?

• Filtration or distillation to remove impurities, followed by disposal in waste water

• Incineration with a combustion reaction

• Directly disposed of as waste water

• Stored in barrels for future use

Which of the following is an example of an H2 receptor antagonist?

• Ranitidine

• Pantoprazole

• Omeprazole

• Esomeprazole

Which solvent is less harmful to the environment?

• Hexane

• Water

• Tetrahydrofuran

• Benzene

What must antacids contain in order to neutralize excess stomach acid?

• Strong

• Strong base

• Weak acid

• Weak base