Test 12 MDS

The other most common MDS case with 30-40% cases is

• Refractory Anemia with Excess Blasts (RAEB)

• Refractory cytopenia with unilineage dysplasia (RCUD)

• Refractory cytopenia with multilineage dysplasia (RCMD)

• Refractory anemia with ringed sideroblasts (RARS)

MDS associated with isolated del(5q)

Long arm (q) of CHR 5 is ​ (a)  

No other chromosomal abnormalities

​ (b)   prognosis, low risk of AML transformation

​ (c)   in PB, ​ (d)   in BM

Main features are ​ (e)   and leukopenia

• deleted
• Favorable
• <1% blasts
• <5% blasts
• macrocytic anemia
• Deadly
• added
• microcytic anemia
• Unfavorable

Chronic Myelomonocytic Leukemia (CMML) characteristics

Considered an ​ (a)   and an ​ (b)  

​ (c)   monocytosis in PB; other lab findings ​ (d)  

Anemia, fever, and/or bleeding ​ (e)  

• MDS
• MPN
• Persistent
• variable
• manifestations
• Intermittentant
• concealment
• RPS
• WBC
• stable

Which of these is not a characteristic of Chronic Myelomonocytic Leukemia (CMML)?

• Cytopenia in at least 2 cell lines

• <20% blasts in PB or BM

• Dyshematopoiesis

• Organomegaly

Which of these is not a finding of Atypical Chronic Myeloid Leukemia (aCML)?

• MDS and MPN

• BCR/ABL negative CML

• 30-40% or all MDS cases

• Leukocytosis with neutrophil series primarily involved

aCML findings

​ (a)   immature and mature ​ (b)  

Progression to ​ (c)   leukemia in ​ (d)   of aCML cases

​ (e)   may be elevated, normal or low

• Dysplastic
• neutrophils
• acute
• 25-40%
• LAP score
• 50%
• chronic
• dyplasia
• basophilic
• LOP score

Match the following Prognosis and Therapy of aCML

• similar to acute conditions

• Hematopoiesis

• stem cell or bone marrow potentially curative

• Median Survival

• <2 years

• Supportive

• stimulating agents based on individual needs

• Transplants

• transfusion, iron chelation, antibiotics based on individual needs

• Treatments

Match the following Lymphocyte malignancies.

• disorders that primarily involve the lymphoid organs (lymph nodes, spleen, thymus)

• Lymphopoiesis

• primarily involve the BM and PB

• Cell of Origin

• CLP or more differentiated progenitors of the T, B or NK lineages

• Lymphomas

• lymphoid stem cell (CLP)

  Lymphoblast

  Prolymphocyte

  Lymphocyte

• Leukemias

Choose the 4 stages of lymphopoiesis.

• Lymphoid stem cell (CLP)

• Endothelial cells

• Lymphoblast

• Prolymphocyte

• Lymphocyte

  NK cell

  T cell

  B cell

  Plasma cell

Which of these Lymphoid Malignancies is NOT a mature lymphoid neoplasm?

• Chronic lymphoid leukemias

• Malignant lymphoma

• Plasma cell neoplasms

• acute lymphoblastic leukemia (ALL)