Drug ‘s potency depends ---------------- of that drug to the specific receptor.

-      The ability to bind with the receptor designated as ---------, and the capacity to induce a functional change in the receptor designated as --------------.

A drug which has higher efficacy necessarily confers:

 

• A. Greater safety

• B. lesser side effects

• C. produce more intense response

• D. more expensive

--------- is beneficial in the determination of clinical effectiveness of a drug.

Answer explanation

Potency is an expression of the activity of a drug in terms of the concentration or amount of the drug required to produce a defined effect, whereas clinical efficacy judges the therapeutic effectiveness of the drug in humans.

Choose the correct statement.

• A. If 10 mg of Drug A produces the same response as 100 mg of Drug B, Drug A is more efficacious than Drug B.

• B.If a  drug has high efficacy, it has high potency as well.

• C. Potency is a comparative measure, refers to the different doses of 2 drugs that are needed to produce the different kinds of therapeutic effect

• D. A competitive antagonist increases the ED50

Select the receptor that is located intracellularly/nuclear receptor

• A.   Opioid receptor

• B.    Thyroid hormone receptor

• C.    Adrenergic receptor

• D. Nicotinic receptor

Q.A 16-year-old girl suffering from seasonal rhinitis started a therapy with loratadine, a drug that binds to H1 histamine receptors. Which of the following terms best defines the ability of a drug to bind to a receptor?

• A.Intrinsic activity

• B.Efficacy

• C.Affinity

• D.Receptor activation

You are a clinical consultant for Pfizer Pharmaceutical Company

 Your task -  to screen ten thousand drug analogs to find the most potent beta-2 receptor agonist.

When analysing your data, the biomarker that you should screen for is:

• A.bioavailability

• B.  EC50

• C.  half life

   

• D.efficacy

Which is correct concerning the safety of using warfarin (with a small therapeutic index) versus penicillin (with a large therapeutic index)?

• A. Warfarin is a safer drug because it has a low TI

• B. Warfarin treatment has a high chance of resulting in dangerous adverse effects if bioavailability

  is altered.

• C. The high TI makes penicillin a

  safe drug for all patients.

• D.Penicillin treatment has a high chance of causing dangerous adverse effects if bioavailability is

  altered.

Answer explanation

B. Agents with a low TI (that is, drugs for which dose is critically important) are those drugs for which bioavailability critically alters the therapeutic and adverse effects. incidence of therapeutic or adverse effects

Recent evidence indicates that receptors for many types of G-protein coupled receptors (GPRCs) have constituitive (basal) activity independent of ligand activation. In such systems, specific ligands (inverse agonists) can bind to these receptors, producing effects that are opposite to those of a conventional agonist. In the graph , which drug displays a dose-response relationship consistent with this type of behavior?

• A. Drug A

• B. Drug B

• C. Drug C

• D. Drug D

Answer explanation

Inverse Agonists -

interact with a receptor, but  produces opposite effect of the well recognized  agonist for that receptor