Hypersensitivity and Autoimmune Disease

commonly called allergies, occur within minutes after exposure to antigen

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

cytolysis due to ab and complement

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

deposition of antigen-antibody complexes

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

characterized by tissue damage due to inflammatory responses

* release of cytokines by sensitized T cells

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

* hay fever, asthma, eczema, atopic dermatitis, anaphylaxis to drugs, food allergies, allergy to animals and animal products

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

* leprosy, tuberculin, hashimoto's, poison ivy, type 1 DM, acute and chrinic graft rejection

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

* drug-induced hemolytic anemia, HDN, hyperacute graft rejection, goodpasteur syndrome, rheumatic fever, myasthenia gravis, grave's, type 2 DM

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

* SLE, RA, post streptococcal, glomerulonephritis, vasculitis, serum sickness

• Type I (Immediate)

• Type II (antibody-mediated)

• Type III (immune complex mediated)

• Type IV (hypersensitivity)

Effector Cells:

Basophil, Mast Cell

• Type I

• Type 2

• Type 3

• Type 4

Effector Cells:

PMN, NK, Microorganism

• Type I

• Type 2

• Type 3

• Type 4