PK - ABSORPTION, DISTRIBUTION, EXCRETION, MISC - AC

PLASMA HALF LIFE IS ESSENTIAL FOR

• PLANNING THE FREQUENCY OF DOSING

• DETERMINE THE APPROPRIATE TIMIG FOR A DRUG DOSE

• DETERMINING THE DURATION OF DRUGS EFFECT ON THE BODY

• ALL OF THEM

THE LEVEL OF DRUG IN PLASMA AT WHICH THE DRUG PRODUCES DESIRABLE EFFECTS IS CALLED AS

• TOXIC LEVEL

• PLASMA LEVEL

• THERAPEUTIC LEVEL

• LETHAL LEVEL

AN EXAMPLE OF CLINICALLY SIGNIFICANT PLASMA PROTEIN BINDING ASSOCIATED DRUG INTERACTION IS

• TERTRACYCLINE AND CALCIUM

• PHENOBARBITONE AND BILIRUBIN

• ASPIRIN AND WARFARIN

• PENICILLIN G AND PROBENECID

SIGNIFICANCE OF REDISTRIBUTION ASSOCIATED WITH SINGLE DOSE OF THIOPENTONE SODIUM IS

• RAPID TERMINATION OF ACTION

• LONG ACTION

• SLOW ACTION

• SUSTAINED ACTION

Optimal therapeutic range of plasma concentrations at which most of the patients experience the desired effect is called as

• TOXIC LEVEL

• LETHAL LEVEL

• THERAPEUTIC WINDOW

• SUB THERAPEUTIC LEVEL

THE FORMULA FOR THERAPEUTIC INDEX IN ANIMALS IS

• SLD 50 BY SED 50

• ED 50 BY LD 50

• LD 50 BY TD 50

• LD 50 BY ED 50

WHICH DRUG HAS HIGH THERAPEUTIC INDEX

• DIGOXIN

• LITHIUM

• PENICILLIN G

• PHENYTOIN

AN EXAMPLE FOR A DRUG WHOSE METABOLISM CAN CHANGE FROM FIRST ORDER TO ZERO ORDER KINETICS IS

• AMOXICILLIN

• PARACETAMOL

• INSULIN

• PHENYTOIN

AN EXAMPLE FOR A DRUG WHICH REQUIRES LOADING DOSE IN AMI

• PARACETAMOL

• ASPIRIN

• TRAMADOL

• AMOXICILLIN

AN EXAMPLE FOR DRUG DRUG INTERACTION AT EXCRETION LEVEL IS

• ASPIRIN AND WARFARIN

• VITAMIN K AND BILIRUBIN

• RIFAMPIN AND ORAL CONTRACEPTIVES

• PENICILLIN G AND PROBENICID