SH Lung Cancer

T/F: Lung cancer is the third most common malignancy in the U.S.

• True

• False

Answer explanation

Lung cancer is the second most common malignancy in the US and is the most common cause of cancer-related deaths.

Most patients present with stage _ lung cancer.

• 1

• 2

• 3

• 4 (metastatic)

T/F: Approved chemoprevention includes: NSAIDs, retinoids, inhaled glucocorticoids, vitamin E, and selenium.

• True

• False

Answer explanation

Currently no approved chemoprevention agents.

Most effective screening and prevention and early intervention of lung cancer include:

• avoid tobacco

• eating healthy diet with fruits and vegetables

• eating animal fats

• screening for high-risk individuals

Which histologic classification of lung cancer is aggressive and rapidly growing but responsive to chemotherapy?

• NSCLC

• SCLC

Staging for SCLC includes:

• Limited and Exensive

• TNM staging 1-4

Signs/Symptoms of paraneoplastic syndrome include:

• weight loss, anemia

• Cushing's syndrome, SIADH

• Hypercalcemia

• Pulmonary hypertrophic osteoarthropathy

Stage IA and IB NSCLC treatment:

• surgery alone

• adjuvant therapy (if complete resection not achieved)

• adjuvant therapy alone

• no treatment

Answer explanation

IB tumors and high-risk features may receive adjuvant chemotherapy

Stage IIA and IIB treatment:

• primary: surgery followed by adjuvant chemotherapy

• cisplatin/etoposide, cisplatin/vinorelbine, cisplatin/paclitaxel, cisplatin/pemetrexed

• PD-L1 inhibitor add on

• platinum agent + radiation

Stage III treatment:

• highly individualized

• IIIA non-surgical canidates and no resection and most IIIB: platinum regimen + concurrent radiotherapy

• IIIB and IIIC and unresectable - response to chemotherapy: consolidation therapy w/ PD-L1 (durvalumab).

• Non surgical candidates - chemo + radiation. Non radiation candidates - treat as Stage IV disease.