Pharmacology test 3

Which of the following drug blocks H+ K + ATPase pump reversibly?

• Rabeprazole

• Ranitidine

• Vonoprazan

• Pirenzapine

Answer explanation

Vonoprazan is a newly launched antacid that competes with potassium for binding to the H+ K+ ATPase pump and blocks it reversibly which leads to blockade in both basal and stimulated acid secretion hence acid suppression is faster.

All of the following are GPCR except :

• Mu opioid receptor

• 5HT3 receptor

• D4 receptor

• GABA B receptor

Answer explanation

Of all the given options 5HT3 is an ion channel. Rest of the serotonin receptors are GPCR. GABA A and C are ion channels whereas GABA B is a GPCR.

Drug that is preferred for Lithium induced Diabetes Insipidus is :

• Frusemide

• Triamterene

• Metolazone

• Indapamide

Answer explanation

DOC for Lithium induced DI is Epithelial Na channel blockers like Amiloride or triamterene.

34 yrs female diagnosed with depression is started on Sertraline, however after 3 months of therapy she is diagnosed with atypical depression and Tranylcypromine is planned for starting. How many days after stopping Sertraline the new drug should be started?

• 1 week

• 2 week

• 3 week

• 4 week

Answer explanation

A minimum gap of 14 days are needed between starting a MAO inhibitor and stopping an SSRI to avoid potential life threatening Serotonin syndrome.

Pneumococcal conjugate vaccine will fall under which Drug schedule?

• F1

• C

• G

• H

Answer explanation

Antiserum, Bacterial vaccines fall under Schedule F1.

Schedule C is for Toxins

Schedule G is for drugs that require medical supervision while instaking

Schedule H is for prescription drugs