Cytochemistry

According to the WHO classification , except in leukemias with specific genetic anomalies, the minimal percentage of blasts necessary for a diagnosis of acute leukemia is:

• 10%

• 20%

• 3%

• 50%

A 20-year old patient has an elevated WBC count with 70% blasts, 4% neutrophils, 5% lymphocytesm and 21% monocytes in the peripheral blood. Eosinophils with dysplastic changes are seen in the bone marrow. AML with which of the following karyotypes would be most likely to be seen?

• AML with t(8;21)(q22;q22)

• AML with t(16;16)(p3;q22)

• APL with PML-RARA

• AMLwith t(9;11)(p22;q23)

Which of the following would be considered a sign of potentially favorable prognosis in child with ALL?

• Hyperdiploidy

• Presence of CD19 and CD20

• Absence of trisomy 8

• Presence of BCR/ABL gene

Signs and symptoms of cerebral infiltration with blasts are more commonly seen in:

• AML with recurrent cytogenetic abnormalities

• Therapy-related myeloid neoplasms

• AML with myelodysplasia-related changes

• ALL

An oncology patient exhibiting signs of renal failure with seizures after initial chemotherapy may potentially develop:

• Hyperleukocytosis

• Tumor lysis syndrome

• Acute leukemia secondary to chemotherapy

• Myelodysplasia

Disseminated intravascular coagulation is more often seen in association with leukemia characterized by which of the following mutations?

• t(12;21)(p13;q22)

• t(9;22)(q34;q11.2)

• inv(16)(p13;q22)

• t(15;17)(q22;q12)

Which of the following leukemias affects primarily children, is characterized by an increase in monoblasts and monocytes, and often is associated with gingival and skin involvement?

• Pre-B-lymphoblastic leukemia

• Pure erythroid leukemia

• AML with t(9;11)(p22;q23)

• APL with PML-RARA

A 20 year old patient presents with fatigue, pallor, easy bruising, and swollen gums. Bone marrow examination reveals 82% cells with delicate chromatin and prominent nucleoli that are CD14+, CD4+, CD11b+, and CD36+. Which of the following acute leukemias is likely?

• Minimally differentiated leukemia

• Leukemia of ambiguous lineage

• Acute monoblastic/ monocytic leukemia

• Acute megakaryoblastic leukemia

Pure erythroid leukemia is a disorder involving:

• Pronormoblasts only

• Pronormoblasts and basophilic normoblasts

• All forms of developin RBC precursors

• Equal numbers of pronormoblasts and myeloblasts

A patient with normal of pronormoblasts and myeloblasts 3.0 X 10^9/L abd dysplasia in all cell lines. There are 60% blasts of varying sizes. The blasts stain positive for CD61. The most likely type of leukemia is:

• Acute lymphoblastic

• Acute megakaryoblastic

• Acute monoblastic

• APL with PML-RARA