DENOCI

What is the sequence of steps for bone remodelling?

• Activation, resorption, reversal, formation, and termination
• Activation, quiescence, resorption, reversal, formation, and termination
• Quiescence, activation, reversal, resorption, formation, and termination
• Quiescence, activation, formation, resorption, reversal, and termination

What among the below is false for Bisphosphonates?

• Flu like symptoms
• Supplementation of Ca & Vit. D
• Extensive use in renal compromised patients
• All of the above

What is the concentration of Denosumab in the vial of Denoci?

• 60mg/1.7ml
• 120mg/1.7ml
• 120mg/2.7ml
• 60mg/2.7ml

The following are the Pt Type -Denoci -------------- Except

• Newly diagnosed pts with BM
• Pts. who have experienced SRE
• Patients previously treated with BPs & at risk of SREs
• Pts Previously failed for DMARDs Treatment
• Pts. with compromised renal function

The following are SRE related Events ( Clinically Significant/Serious Consequenses of Bine Metastases)…...... Except?

• Broken Fractures
• A Need for Bone Surgery
• A Need for Radiation treatments to the Bone
• Pressure on Spinal Cord(Compression)
• osteoporosis

Denosumab Benefits are-

• Convenience of sc dosing q4w
• No dose adjustments/monitoring required
• Can be used in renal impaired patients
• Rare acute-phase reactions occur after denosumab
• Greater suppression of bone turnover markers

Approved Indication of Denosumab

• Prevention of SRE in Pts with MM and In pts with BM from Solid tumours
• Treatment of Hypercalcemia of Malignancy refractory to bisphosphonates therapy
• Both A and B

Dose of Denoci- MM and BM from Solid Tumors

• 120mg SC Every 4 Week in the upper Arm, Upper thigh or Abdomen
• 120mg SC for 4 weeks in the Upper Arm, Upper thigh or abdomen with Additional 120mg doses on Day 8 and day 15 for 1st month
• None of the above

What is function of osteoblasts & osteoclasts?

• Bone deformation & Bone resorption
• Bone formation & Bone resorption
• Bone resorption & Bone deformation
• None of the above

What is true for Denosumab?

• Murine mAB
• Chimeric mAB
• Humanized mAB
• Fully human mAB