Antihyperlipidaemics

Which of these is a long acting statin?

• Atorvastatin
• Simvastatin
• Lovastatin

• Pravastatin

What interaction occurs between statins and grapefruit juice?

• Statins and grapefruit juice have no interaction
• Reduced absorption

• Enzyme inhibition

• Increased excretion of statin

Which is a common adverse effect of fibrates?

• Gallstones

• Gout

• Atherosclerosis

• Bronchoconstriction

Where does evolocumab act?

• HMG CoA reductase

• PCSK9

• NPC1L1

• PPAR Gamma

Which of these are the mechanisms of action for bile acid binding resins?

• Reduced cholesterol absorption from GI tract

• Reduced excretion of cholesterol

• Increased hepatic conversion of cholesterol to bile acids

• Inhibition of HMG CoA reductase

Which are the mechanisms of fibrate action?

• Activation of ppar gamma

• Increased LDL release from hepatocyte

• Reduced VLDL secretion by liver

• Reduced lipid absorption from gut

Which are examples of fibrates?

• Nicotinamide

• Gemfibrozil

• Bezafibrate

• Clofibrate

Which substrate is involved in statin action?

• acetylCoA

• Mevalonate

• pyruvate

• apolipoprotein

Which are common adverse effects of statins?

• Myalgia

• Hepatotoxicity

• Hair loss, constipation, and blurred vision
• Bradycardia

The mechanism of statin action includes

• Inhibition of HMG CoA reductase

• Upregulation of LDL receptors

• Increased LDL reuptake

• Increased triglycerides