Practice tutor week 4

The pharmacokinetic parameter is used to determine the amount of drug in the central compartment at plasma concentration Cx:

• Vdss

• AUC 0→infinity

• V1

• Clt

• Vd(area)

The pharmacokinetic parameter allows the determination of the amount of drug in the body at plasma concentration Cx:

• VDss

• AUC 0→infinity

• V1

• Clearance

• Vd(area)

Drug concentrations in this compartment are decreasing during the beta phase

• Tissue compartment only

• Plasma compartment only

• Plasma and central compartment only

• Tissue and plasma compartment only

hybrid or macro rate constants obtainable from evaluating this data are;

• Alpha

• Alpha and beta

• Alpha, beta, and k12

• 
  K12,k21, and kel

• Beta and k10

Drug elimination occurs during the distribution phase True or False

• True

• False

Pseudo-distribution equilibrium occurs during the elimination phase or post

absorption phase

• True

• False

When the absorption rate and the elimination rate become equal after an oral dose,

pseudo-distribution equilibrium occurs

• True

• False

The oral absorption pharmacokinetic model where kel is greater than ka is Flip -flop model

• True

• False

A drug absorption rate is relevant for which of the following routes of drug administration:

• Oral

• Subcutaneous

• Intravenous

• Intramuscular

After an oral dose and before Cmax occurs, the absorption rate is ___________ the elimination rate

• faster

• slower

• equal