Quiz on Xist, Dosage Compensation, Gene Expression, Nanog, UMAP, SNP, and Development

What is Xist?

• Master regulator of x chromosome inactivation

• Activates expression of the x chromosome

• Is activated by Tsix

• Noncoding RNA that silences x chromosomes

How does dosage compensation in worms work?

• They double express the X chromosome without dosage compensation

• Complete silencing of one X chromosome

• Silencing of one half of each x chromosome

• Overexpression of the male x chromosome

How is gene expression measured in Pacini et al?

• bulk-RNA sequencing

• Western blots

• single cell RNA seq

• PCR

What was Nanog associated with?

• Methyltransferase

• Differentiation

• Ubiquitin Ligase

• North American Network Operators Group

What is UMAP?

• Uniform Manifold Approximation and Projection

• A Dimensionality Reduction Analysis

• User Modeling, Adaptation, and Personalization

• Unidades Militares para Ayuda a la Producción

What does SNP stand for?

• Single Nucleotide Polymorphisms

• Special Needs Plan

• Single Nanometer Pixel

• Sodium NitroPrusside

Are genes expressed in a BA or MA fashion during development and XCI?

• Are these some US states I don't know about?

• Spectrum of BA to MA expression

• BA expression throughout all of development

• Transition from MA to BA expression

Which of the chromosomes is silenced more efficiently?

• Cast chromosome

• B6 chromosome

• Depends on the mouse

• They are silenced at the same rate

Which gene escapes repression from the CAST chromosome?

• Klhl13

• Pir

• Hprt

• XCI

MA -> BA

• Yes

• No

• Maybe So