Cancer Gen Biology

Cancer creates abnormal cells by:

• Disrupting the cell cycle

• DNA damage

• ATP synthesis

• controlled growth of cells

What genes can disturb the cell cycle if they are mutated?

• Tumor suppressor genes

• RNA

• Proteins

• Proto-oncogenes

• Cell cycle

What are oncogenes?

• Cell death

• DNA repair

• Normal genes that become mutated

• Normal genes with regular cell growth

Only one copy of proto-oncogene needs to undergo a mutation for uncontrolled division to take place and cause cancer?

• True

• False

What is an example of a tumor suppressor gene?

• G0

• S phase

• G1

• p53

Only one copy of a tumor suppressor gene needs to lose function for a cancerous phenotype to develop?

• True

• False

What is a retinoblastoma susceptibility gene?

• Predisposes individuals for a rare form of cancer in the immune system

• Predisposes individuals for a rare form of cancer in the retina of the eye

• Predisposes individuals for a rare form of cancer in the pancreas.

• Predisposes individuals for a rare form of cancer in the skin

What is TRUE of p53 genes?

• Plays a role in the G2M checkpoint

• Plays a role in the G1 checkpoint

• Monitors DNA damage and repair

• All of the above are correct

If DNA is damaged, a p53 gene will halt cell division to instigate DNA repair

• True

• False

Why is cell cycle regulation important in preventing diseases like cancer?

• 
  It ensures proper cell division

• It regulates cell metabolism

• It prevents DNA damage

• It promotes apoptosis