ROSapoptosis

thioredoxin prevents apoptosis by forming an inhibitory heterodimeric disulfide bridge to ______.

• Ask1

• Thioredoxin

• Bim

• Bax

• JNK

required to reduce peroxiredoxin

• Ask1

• Thioredoxin

• Peroxiredoxin

• Superoxide

• JNK

when Bcl2 is removed from the mitochondrial outer membrane, this puts holes in it to activate apoptosome formation

• Bax

• JNK

• Ask1

• Bim

• Thioredoxin

Ask1 activates a kinase cascade to activate a kinase named _____.

• Thioredoxin

• Bax

• Bim

• Ask1

• JNK

when phosphorylated by JNK, removes Bcl2 from the mitochondrial outer membrane

• Bim

• Ask1

• JNK

• Thioredoxin

• Bax

Semiquinone radicals react with molecular oxygen to form _____.

• Superoxide

• JNK

• Ask1

• Thioredoxin

• Bax

produces semiquinone radicals when deprived of matrix H+ during hyperglycemia

• Succinate dehydrogenase (Complex II)

• Ask1

• Thioredoxin

• Bax

• JNK

donates hydrides from cysteines to reduce hydrogen peroxide

• Ask1

• Bax

• SOD

• Peroxiredoxin

• JNK

converts superoxides to hydrogen peroxide

• SOD

• Ask1

• JNK

• Bax

• Thioredoxin