Pharm exam 3: 1 com model

After IV administration, drugs distributes relatively ____

• slowly

• rapidly

Rate and extent of tissue distribution is dependent on

• Blood flow to organs

• Physiochemical properties of drug

• affinity of tissues fro drug

• size of organ

Which organs have large capacity for drug distribution?

• large organs

• small organs

Under what situation can we treat the body as a single compartment?

• if drug distributes evenly

• if drug distributes rapidly

• if drug distributes slowly

Select all of the assumptions of a 1 compartment model.

• body is a single uniform compartment

• instant administration of entire dose

• rapid distribution throughout body

• drug elimination starts immediately

What is the simplest representation of drug disposition?

• 2 compartment model

• 1 compartment model

What describes a "well-stirred" model?

• not uniform

• uniform

• instantaneous distribution

• continual, stead distribution

VD is ___

• actual volume

• theoretical volume

Which represents administration of a dose into a single compartment?

• VD

• k

• IV

• DB

The proportion between the dose (DB) and the concentration in plasma (C0/P) immediately after being injected into the body.

• IV

• k

• VD