Cell Division and Cancer Genes Quiz

What is the purpose of the cell cycle?

• To create more cells

• To prevent cell division

• To regulate gene expression

• To repair damaged cells

What is the main cause of cancer?

• Exposure to mutagens

• Mutations in genes controlling cellular growth

• Unregulated cell division

• Errors in DNA replication

Which type of gene mutations cause cells to divide uncontrollably?

• Tumor suppressor genes

• Oncogenes

• Neither oncogenes nor tumor suppressor genes

• Both oncogenes and tumor suppressor genes

Which gene is commonly mutated in cancer cells?

• P53 gene

• RB gene

• WT1 gene

• Merlin gene

What is Li-Fraumeni Syndrome?

• A syndrome caused by mutations in the Merlin gene

• A syndrome caused by mutations in the WT1 gene

• A syndrome caused by mutations in the RB gene

• A syndrome caused by mutations in the P53 gene

What is the role of p53 in tumor suppression?

• All of the above

• Arresting cell growth

• Regulating DNA damage repair

• Initiating cell death

What is the two-hit hypothesis?

• Only one allele of a tumor suppressor gene needs to be mutated for cancer to occur

• Both alleles of an oncogene need to be mutated for cancer to occur

• Only one allele of an oncogene needs to be mutated for cancer to occur

• Both alleles of a tumor suppressor gene need to be mutated for cancer to occur

What is the purpose of RFLP analysis?

• To separate DNA fragments by size using gel electrophoresis

• All of the above

• To digest DNA samples with restriction enzymes

• To amplify DNA samples

What is the significance of p53 hot spots?

• They are regions in the p53 protein that are highly conserved

• They are regions in the p53 gene that are resistant to mutation

• They are regions in the p53 protein that affect its structure

• They are regions in the p53 gene that are frequently mutated in cancer

Why does Valerie's tumor DNA sample have fewer bands than the peripheral blood sample?

• The tumor DNA has fewer copies of the p53 gene

• The tumor DNA has a different p53 gene sequence

• The tumor DNA has more copies of the p53 gene

• The tumor DNA has mutations in the p53 gene