Fatty Acid Synthesis and Breakdown Quiz

Free fatty acids in the plasma.....................................

• Circulate in the unbound state

• Bind to lipoproteins and circulated

• Bind to albumin and circulated

• Bind to a fatty acid-binding protein and circulated

In what compartment does the de novo fatty acid synthesis occur?

• Mitochondria

• Peroxisome

• Endoplasmic reticulum

• Cytosol

What is the precursor for fatty acid synthesis?

• Acetyl CoA

• Propionyl CoA

• Succinyl CoA

• Acetoacetyl CoA

The conversion of acetyl CoA to malonyl CoA is the rate-limiting step in fatty acid synthesis. Which of the following enzyme catalyzes the above-mentioned reaction?

• Acetyl CoA carboxylase

• Malonyl CoA synthetase

• Acetyl CoA decarboxylase

• Malonyl CoA synthase

The acetyl CoA is produced in the mitochondria and must be transported into the cytosol for the synthesis of fatty acids. Which of the following is true regarding the transport of Acetyl CoA?

• Acetyl CoA is diffused from the mitochondrial membrane

• Acetyl CoA is transported by its specific transporter protein

• Acetyl CoA is converted into pyruvate, enters into the cytosol and acetyl CoA is regenerated

• Acetyl CoA is converted into citrate, enters into the cytosol and acetyl CoA is regenerated.

What is the allosteric regulator of acetyl CoA carboxylase?

• Fatty acid

• ATP

• Citrate

• Acetyl CoA

Which of the following event inactivates acetyl CoA carboxylase?

• ADP-Ribosylation

• Glycosylation

• Phosphorylation

• Farnesylation

Which of the following is not a positive regulator of acetyl CoA carboxylase?

• Excess calories

• Insulin

• Citrate

• Long-chain fatty acid

Which of the following enzyme statement is not true regarding fatty acid synthase?

• Fatty acid synthase is a multifunctional enzyme

• Fatty acid synthase is active as a dimer

• Fatty acid synthase is activated by high-calorie food

• Fatty acid synthase complex is inhibited by its phosphorylation

What form of energy is required for fatty acid biosynthesis?

• ATP

• NADH

• NADPH

• FADH2