Causes of fatigue

Reduces the capacity for high intensity contractions

• Disrupted brain activity

• ATP Depletion

• Hypoglycemia

• Metabolic acidosis

Less glucose is available for use as fuel, reducing the rate at which muscle cells can produce ATP

• Hypoglycemia

• Hypovolemia

• Hyperthermia

• Glycogen Depletion

Reduces the uptake and use of glucose by brain, nerves, and muscle cells, making exercise feel difficult

• Hypovolemia

• Hypoglycemia

• Hyperthermia

• ATP Depletion

Reduces the desire to continue to exercise and the muscular coordination required to maintain exercise

• Disrupted neural transmission

• Metabolic Acidosis

• Disrupted brain activity

• PCr Depletion

Reduces the ability of the muscle cells to contract. Increases breathing rate.

• Hyperthermia

• Metabolic Acidosis

• ATP Depletion

• Disrupted brain activity

Reduces cardiac output, the ability of the heart to supply blood to working muscles

• Metabolic Acidosis

• Hyperthermia

• Hypovolemia

• Hypoglycemia

Reduces the capacity for high intensity contractions

• PCr Depletion

• Glycogen Depletion

• Metabolic Acidosis

• Appetite

Makes exercise feel more difficult and reduces the brain'ss desire to continue exercise

• Hypovolemia

• Metabolic Acidosis

• Hyperthermia

• Hypoglycemia

Alters signals to and from muscle, negatively affecting coordination required to maintain exercise

• Disrupted neural transmission

• ATP Depletion

• PCr Depletion

• Disrupted brain activity