Corso Exam 2 Special Senses

Reorder the steps of epinephrine/NE binding

• activate trimeric G proteins (Gs)

• activate adenylate cyclase

• activate PKA

• Epi/NE bind to β-adrenergic receptors

• synthesize cAMP

Epinephrine is responsible for

• increasing PKA

• decreasing PKA

• decreasing Ca²⁺, Na⁺

• increasing Ca²⁺

• increasing Ca²⁺, Na⁺

What receptor is activated with sugar

• β-adrenergic receptor

• Olfactory receptor 1

• Rhodopsin

• Serpentine receptor

• Vasopressor receptor

What receptor is activated with light

• β-adrenergic receptor

• Olfactory receptor 1

• Rhodopsin

• Serpentine receptor

• Vasopressor receptor

Which G protein does serpentine receptors activate

• G-gustatory

• Adenylate cyclase

• G-olfactory

• Gs

• Gi

Reorder the sweet receptor pathway

• sweet taste

• activates serpentine receptor

• activates trimeric G-gustatory (for taste)

• activates PKA and closes outward K⁺

• activates adenylate cyclase and cAMP

Reorder the steps of the light 2nd messenger system pathway

• activates a trimeric G protein, Transducin

• affect phosphodiesterase

• photon of light hits a heptahelical serpentine protein called rhodopsin

• decreases cGMP levels

• retinal (molecule inside rhodopsin) has a cis bond that gets flipped to a trans bond

In the olfactory pathway, an odorant binds to a receptor to activate ​ (a)   which will activate ​ (b)   to make cAMP. cAMP opens ​ (c)   channels which then opens ​ (d)   . This will cause depolarization

• G-protein
• AC
• inward Ca+
• outward Cl-
• PDE
• PLC
• Transducin
• inward Na+
• inward Cl-
• outward K+

Where is the heptahelical serpentine receptor

Where is the G protein