MAJOR HISTOCOMPATIBILITY COMPLEX

Transplants last longer if the HLA antigens from the recipient and the donor are closely matched.

• Paternity testing

• Platelet transfusion

• Transplantation

HLA loci are polymorphic and recombination is rare. HLA inheritance patterns can exclude fathers with approximately 99% accuracy

• Paternity testing

• Platelet transfusion

• Transplantation

HLA B-27 is associated with

• Ankylosing spondylitis

• Myeloperoxidase (MPO) deficiency

• Chronic granulomatous disease

Answer explanation

Ankylosing spondylitis- A type of arthritis that causes inflammation in the joints and ligaments of the spine.

Combination of inherited HLA alleles

• HLA

• Haplotype

• Genotype

Two haplotypes (one from each parent)

• HLA

• Haplotype

• Genotype

Are cell surface markers that allow immune cells to distinguish "self from "nonself."

• HLA

• Haplotype

• Genotype

HLA complex located in;

• Chromosome 3

• Chromosome 6

• Chromosome 9

HLA Antigens found on

• All nucleated cells

• Red blood cells

• White blood cells

Complement proteins, TNFa and (3, and other proteins (e.g., heat shock protein) not associated with cell membrane surfaces

• Class I

• Class II

• Class III

Molecules located on the surface of monocytes, macrophages, B cells, activated T cells, dendritic cells, Langerhans' cells, and some epithelial cells

• Class I

• Class II

• Class III

Answer explanation

Antigen-presenting cells with MHC II molecules present antigens to T helper cells