Tricyclic Antidepressants

TCAs achieve their antidepressant action by blocking the reuptake of which 2 main biogenic amines in the CNS?

• serotonin

• norepinephrine

• dopamine

• tyramine

When a TCA has a side chain with a primary amine, this makes it

• inactive

• more potent blockers of NE uptake an tend to be less sedating

• more potent blockers of 5-HT uptake and tend to be more sedating

Answer explanation

When a TCA has a side chain with a secondary amine, this makes it

• inactive

• more potent blockers of NE uptake an tend to be less sedating

• more potent blockers of 5-HT uptake and tend to be more sedating

Answer explanation

When a TCA has a side chain with a tertiary amine, this makes it

• inactive

• more potent blockers of NE uptake an tend to be less sedating

• more potent blockers of 5-HT uptake and tend to be more sedating

Answer explanation

Which of the following are Non-typical TCAs?

• Maprotiline

• Amoxapine

• Amitriptyline

• Desiramine

Answer explanation

Which of the following can cause urine discoloration?

• Maprotiline

• Amoxapine

• Amitriptyline

• Desiramine

Answer explanation

Which of the following are less active and cardiotoxic?

• 
• 
• 
• 

Answer explanation

hydroxylation= less active and cardiotoxic

Which of the following is inactive?

• 
• 
• 
• 

Answer explanation

N-demethylation, it is a primary amine

conjugates are also inactive

Which of the following is active?

• 
• 
• 
• 

Answer explanation

N-demethylation, it is a secondary amine

Compounds containing C in place of N in ring doesn't undergo hydroxylation

• true

• false