Patho 3

What is the main type of demyelinating disease in the CNS?

• Neuromyelitis optica

• Central pontine myelinolysis

• Multiple sclerosis

• Post infectious demyelination

Which autoimmune disease affects mainly the optic nerve and spinal cord?

• Multiple sclerosis

• Central pontine myelinolysis

• Post infectious demyelination

• Neuromyelitis optica

What is the main role of CD4 T lymphocytes in multiple sclerosis?

• Produce antibodies

• Activate macrophages

• Destroy myelin

• Secretes inferferon alpha

What is the characteristic feature of quiescent plaques in multiple sclerosis?

• Astrocytic proliferation

• Inflammation

• Macrophages containing myelin debris

• Myelin breakdown

Which type of demyelinating disease occurs after viral infections?

• Post infectious demyelination

• Multiple sclerosis

• Neuromyelitis optica

• Central pontine myelinolysis

What is the “main” symptom of central pontine myelinolysis?

• Sensory symptoms

• Motor dysfunction

• Locked out syndrome

• Visual disturbances

Which type of leukodystrophy is inherited in an autosomal recessive manner?

• X-linked leukodystrophies

• Myelin protein mutations

• Balance between destruction and synthesis

• Dysmyelinating diseases

What is the cause of demyelination in post infectious demyelination?

• Iatrogenic settings

• Autoimmune response due to cross reactivity

• Toxins or chemicals

• Direct effect of the virus on myelin

Which type of T cells play a role in myelin destruction in multiple sclerosis?

• CD4 and B lymphocytes

• CD4 and T helper 17

• CD4 and CD8

• CD8 and macrophages