Understanding Sickle Cell Disease

What is the main cause of sickle cell disease?

• A mutation in a single gene

• A lifestyle choice

• Exposure to toxins

• A bacterial infection

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What shape do red blood cells take in individuals with sickle cell disease?

• Oval

• Triangle

• Crescent moon or sickle shape

• Square

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Why is sickle cell disease puzzling in terms of evolution?

• It provides immunity to all diseases

• It cannot be inherited

• It is a relatively common trait despite being harmful

• It only affects animals

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What discovery did Tony Allison make regarding sickle cell disease?

• It offers an advantage against malaria

• It is most common in cold climates

• It is caused by a virus

• It can be cured with antibiotics

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NGSS.HS-LS4-2

How does the sickle cell trait affect malaria parasites?

• It enhances the parasite's growth

• It makes it harder for the parasite to feed on hemoglobin

• It makes the host immune to all parasites

• It has no effect on the parasite

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What is the role of a pediatric hematologist?

• They specialize in pediatric surgery

• They treat children with blood disorders

• They research new pediatric medicines

• They focus on pediatric nutrition

What is the significance of the sickle cell allele in relation to malaria?

• It makes malaria undetectable

• It is protective against malaria in heterozygotes

• It has no impact on malaria

• It increases the severity of malaria

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How did Tony Allison confirm the relationship between sickle cell trait and malaria?

• By creating a vaccine for malaria

• By surveying people's opinions on malaria

• By genetic engineering

• By comparing parasite counts in children with and without the trait