Immunology Exam 3

B lymphocytes are made in the:

• blood stream

• bone marrow

• liver

• thymus

MHC class I molecules are heterodimers consisting of _____.

• a chain and B2-microglobulin

• a chain and B chain

• heavy chain and light chain

• all of the above

• none of the above

Which of the following is true for the structures of the MHC class II molecules?

• its peptide binding groove is formed by a1/B1

• its peptide binding groove is closed at both ends

• the general size of its bound peptides is 8-9 amino acids

• all of the above

• none of the above

This type of cell will leave the bone marrow and complete maturation in the spleen

• hematopoietic stem cell

• immature B cell

• pro-B cell

• pro-T cell

Tags

NGSS.HS-LS1-4

Which of the following is true regarding B-cell development?

• B cells complete maturation in the spleen

• B cells are mostly developed when they leave the bone marrow

• self reactive B cells may be eliminated through apoptosis

• self reactive B cells may be rendered unreactive (anergic)

• all of the above

Tags

NGSS.HS-LS1-4

V-DJ recombination occurs during which phase of B cell development?

• activated B cell

• mature B cell

• naive B cell

• pre B cell

• immature B cell

The developmental stages of B cells in the bone marrow are defined by:

• changes in cell surface markers

• changes in gene expression

• BCR gene rearrangements

• all of the above

• none of the above

What could occur to the immature B cells in the bone marrow if they are found to have self reactive BCRs?

• clonal deletion

• light chain receptor editing

• development of anergy

• all of the above

• none of the above

What type of immunoglobulin gene rearrangement occurs during B cell progenitor development?

• DH-JH rearrangement

• DL-JL rearrangement

• both heavy and light chain rearrangement

• VH-DJH rearrangement

• VL-DJL rearrangement

Superantigens:

• are harmless

• bind to MHC class I outside the peptide binding groove

• activate CD8+ T cells

• bind to MHC class II outside the peptide binding groove

• are processed