Biochem 4

Fatty acid oxidation involves what 4 steps

• Oxidation

• Hydrolysis

• Oxidation

• Thiolysis

• Phosphorylation

In B oxidation, The carboxyl group at C1 is activated by

• Thiolation

• Phosphorylation

• addition of acetly coA

• addition of a carbonyl group

Fatty Acid oxidation takes place in the mitochondrial matrix

• True

• False

Cartinine acyl transferase 1 is activated by

• low blood glucose

• high glucagon

• PKA AMPK

• high carbohydrate

• after a high fat diet

Carnitine acyl transferase 1 is inhibited by

• High carbohydrates

• High glucose

• Malonyl-CoA

• Acetyl Co-A carboxylase

• high insulin

What inhibits B- hydroxy acyl CoA dehydrogenase

• High NADH/NAD+ ratio

• Low NADH/NAD+

What inhibits thiolase

• high acetyl-CoA

• low acetyl CoA

Select the steps of B oxidation in peroxisomes

• dehydrogenation

• addition of water to resulting double bond

• oxidation of B-hydroxyacyl-CoA to a ketone

• thiolytic cleavage by coenzyme A

In perixosomes, the oxidase the introduces the double bond passes electrons to O2 producing H2O2 which is then cleaved to H2O and O2.

• True

• False

What molecule generates the active form of fatty acids before B oxidation

• Coenzyme A

• Biotin

• Carnitine

• Hexokinase