Simple Test

Naphthol AS-D chloroacetate esterase
(specific) is usually positive in ......
cells, and alphanaphthyl acetate esterase (nonspecific)
is useful for identifying blast cells of ........
lineage.

• A. Granulocytic; monocytic
  
  
  
  

• B. Monocytic; granulocytic

• C. Granulocytic; lymphocytic

• D. Monocytic; lymphocytic

Side angle scatter in a laser-based cell
counting system is used to measure

• A. Cell size

• B. Cytoplasmic granularity

• C. Cell number

• D. Immunologic (antigenic) identification

Terminal deoxyribonucleotidyl transferase
(TdT) is present in

• A. Precursor B and precursor T lymphoid
  cells

• B. Mature B and T lymphocytes

• C. Precursor B cells and mature
  B lymphocytes

• D. Precursor T cells and mature
  T lymphocytes

Answer explanation

Terminal deoxyribonucleotidyl transferase
(TdT) is a nuclear enzyme (DNA polymerase)
found in stem cells and precursor B and T lymphoid cells. High levels of TdT are found in 90%
of ALLs. TdT has been found in up to 10% of
cases of AML (FAB MO and Ml), but in lower
levels than are present in ALL. This enzyme is
not found in mature lymphocytes

Coarse PAS positivity may be found in the
leukemic cells of

• A. Acute myeloblastic leukemia (FAB
  type Ml)

• B. Acute lymphoblastic leukemia (FAB
  type LI)

• C. Acute myelomonocytic leukemia
  (FAB type M4)

• 
  
  D. Acute monocytic leukemia (FAB
  type M5)
  

The blast cells shown in Color Plate 18 •
are CD14 and CD33 positive, Sudan black
B positive, specific esterase positive, and
nonspecific esterase positive. Which type
of acute leukemia is most consistent with
the immunophenotyping and cytochemical
staining results?

• A. Acute lymphoblastic leukemia, T cell
  type

• B. Acute erythroleukemia

• C. Acute myelomonocytic leukemia

• D. Acute monocytic leukemia

A "shift to the left," when used to describe
a cell population , refers to

• A. Increased cells in the blood due to a
  redistribution of blood pools

• B. An increase in immature blood cells
  following release of bone marrow
  pools

• C. A higher percentage of lymphocytes
  than neutrophils

. What is the major phagocytic cell involved
in the initial defense against bacterial
pathogens?

• A. Neutrophil

• B. Eosinophil

• C. Basophil

• D. Monocyte

Which of the following test results is not
characteristic of DIG?

• A. Decreased fibrinogen concentration

• B. Positive test for degradation products

• C. Decreased platelet count

• D. Increased antithrombin

A 65-year-old patient in the emergency
department has a normal D-dimer and an
elevated FDP result. These results are
consistent with the presence of degradation
products of

• A. Non-cross-linked fibrin

• B. Cross-linked fibrin

• C. Fibrinogen

• D. Plasmin

The coagulation factors having a sexlinked recessive inheritance pattern are

• A. Factor V and factor VIII

• B. Factor VIII and factor IX

• C. Factor IX and factor X

• D. von Willebrand factor and factor VIII