CAR-T Cell Quiz MBIOS

What are CAR-T cells?

• Engineered synthetic receptors that redirect lymphocytes to recognize and eliminate cells expressing a specific target antigen

• A type of stem cell that can differentiate into any type of cell in the body

• A type of cancer cell that is resistant to chemotherapy and radiation

• A type of immune cell that is responsible for allergic reactions

Which of the following is a limitation of CAR-T cell therapy?

• Limited efficacy against solid tumors

• Inhibition and resistance in B cell malignancies

• Antigen escape

• All of the above

How does overexpression of FOXO1 affect CAR-T cells?

• It promotes a stem-like phenotype in CAR T cells

• It inhibits the function of CAR T cells

• It makes CAR T cells more susceptible to chemotherapy and radiation

• It causes CAR T cells to differentiate into other types of cells

How do CAR-T cells differ from traditional cancer therapy methods such as chemotherapy and radiation?

What are the potential risks and challenges associated with engineering CAR T-cells to overexpress FOXO1?