Ketogenesis SSCY 1103

Ketogenesis occurs primarily in ______ of liver cells

• Mitochondria

• Cytosol

• Endoplasmic reticulum

• Golgi apparatus

The primary tissue that utilizes ketone bodies for energy is

• Brain

• Liver

• Skeletal muscle

• Kidneys

Which of the following are ketone bodies

• acetoacetate

• acetone

• ꞵ-hydroxy butyrate

• all of the above

The enzyme that catalyzes the conversion of acetoacetate to beta-hydroxybutyrate is

• Acetoacetate dehydrogenase

• HMG-CoA synthase

• 3-Hydroxybutyrate dehydrogenase

• Pyruvate carboxylase

In ketone body metabolism, the primary precursor for the synthesis of ketone bodies is

• Pyruvate

• Lactate

• Glucose

• Acetyl-CoA

Below are the causes of ketogenesis EXCEPT

• Consuming a diet high in fats and proteins

• Not eating for 40 hours

• Having uncontrolled diabetes mellitus

• Going without food for 8 hours

• Exercising excessively

What triggers Ketogenesis?

• Depletion of Acetyl CoA

• Oxaloacetate depleting, Acetyl CoA increases

• Oxaloacetate increases, Acetyl CoA depletes

Why does oxaloacetate depletion occurs?

• Oxaloacetate is used for glycolysis

• Oxaloacetate is used for beta oxidation

• Oxaloacetate is used for gluconeogenesis