WBCs TEST

Functionally, white blood cells are divided into?

• A. Granulocytes, nongranulocytes

• B. Polymorphonuclears, mononuclears

• C. Phagocytes, immunocytes

• D. Granulocytes, lymphocytes

A "shift to the left," when used to describe a cell population refers to
.............

• A. Increased cells in the blood due to a
  redistribution of blood pools

• B. An increase in immature blood cells
  following release of bone marrow
  pools

• C. A cell production "hiatus" or gap

• D. A higher percentage of lymphocytes
  than neutrophils

Which of the following statements about basophils is false?

• A. Morphologically, basophils resemble
  tissue mast cells.

• B. Membrane receptors bind IgG,
  initiating anaphylactic reactions.

• C. Basophilic granules contain heparin
  and histamine.

• D. Granules are water soluble.

Which of the following statements is
correct?

• A. Hypersegmented neutrophils have four
  nuclear lobes.

• B. Auer rods are composed of fused
  primary granules.

• C. Toxic granules are prominent
  secondary granules.

• D. Dohle bodies are agranular patches of
  DNA.

Which of the following are indicators of a neutrophilic response to tissue damage or
inflammatory stimuli?

• A. Toxic granules and Dohle bodies in
  the neutrophils

• B. Vacuoles and Barr bodies in the
  neutrophils

• C. Hypersegmented neutrophils and
  Auer rods

• D. Pyknotic neutrophils and Russell
  bodies

Which of the following statements does not correctly describe the WHO (World Health Organization) classification of
hematopoietic neoplasms?

• A. Acute leukemia is defined as the
  presence of at least 20% bone marrow
  blasts.

• B. Diagnosis is based on cellular
  morphology and cytochemistry.

• C. It groups lymphoid disorders into
  B cell, T/NK cell, and Hodgkin
  lymphoma.

• D. Diagnostic criteria include morphologic, cytochemical, immunologic,
  cytogenetic, and molecular features

Which of the following are characteristic findings in Waldenstrom disease?

• A. Increased IgA and
  hepatosplenomegaly

• B. Increased IgE and renal failure

• C. Increased IgG and hypercalcemia

• D. Increased IgM and blood hyperviscosity

An adult patient with massive splenomegaly has mild anemia, a slightly
elevated WBC count, and an LAP score of 170. The blood smear shows teardrop
erythrocytes and Leukoerythroblastosis. These findings are most consistent with

• A. Chronic myelogenous leukemia

• B. Idiopathic myelofibrosis

• C. Primary polycythemia

• D. Primary thrombocythemia

Answer explanation

The bone marrow is progressively replaced
by fibrotic tissue in myelofibrosis, a chronic
myeloproliferative disorder. Attempts to aspirate
bone marrow usually result in a "dry tap." A
biopsy stain demonstrates increased fibrosis
(fibroblasts are thought to be stimulated by
megakaryocytes). The presence of teardropshaped red blood cells is an important feature of
myelofibrosis. In addition, abnormal platelets, a
leukoerythroblastic blood profile and myeloid
metaplasia in the spleen and liver are often associated with this disease. A high LAP score (reference range 13-160) and increased RBC mass
are found in polycythemia vera, but the LAP
score is low in chronic myelogenous leukemia

Which of the following statements about hairy cell leukemia is true?

• A. It is an acute disease, primarily
  affecting young adults.

• B. Splenomegaly is an unusual finding.
  .

• C. Hairy cells contain tartrate-resistant
  acid phosphatase

• D. Hairy cells are abnormal T lymphocytes.

In which anomaly is a failure of granulocytes to divide beyond the band or two lobed stage observed?

• A. Pelger-Huet

• B. May-Hegglin

• C. Alder-Reilly

• D. Chediak-Higashi