Cell Injury - Pathology

What is the earliest morphologic manifestation of reversible cell injury?

• Ribosomal detachment

• Cellular swelling

• Plasma membrane changes

• Nuclear changes

Which of the following is a consequence of decreased ATP levels in reversible cell injury?

• Increased protein synthesis

• Activation of degradative enzymes

• Decreased activity of Na+K+ Pump

• Lysosomal rupture

What nuclear change is associated with reversible cell injury?

• Pyknosis

• Karyolysis

• Chromatin clumping

• Karyorrhexis

In irreversible cell injury, which enzyme's activation is associated with plasma membrane breakdown?

• ATPase

• Lipase

• Caspase

• None of the above

Which morphological change indicates irreversible cell injury?

• Myelin figures

• Ribosomal detachment

• Mitochondrial dysfunction

• Membrane blebbing

Which term describes nuclear fragmentation during irreversible cell injury?

• Pyknosis

• Karyorrhexis

• Karyolysis

• Chromatin clumping

What happens to lysosomes during irreversible cell injury?

• They detach from the endoplasmic reticulum

• They rupture, leading to autolysis

• They swell but remain intact

• They aggregate with mitochondria

Myelin figures are seen in?

• Reversible cell injury

• Irreversible cell injury

• Niemann-Pick's cells

• All of the above mentioned conditions

What is the consequence of increased mitochondrial permeability in irreversible cell injury?

• Increased ATP production

• Decreased electron transport chain activity

• Ribosomal reattachment

• Decreased cellular swelling

What kind of densities/inclusions in mitochondria indicate irreversible cell injury?

• Chromatin clumps

• Myelin figures

• Amorphous densities

• Ribosomal inclusions