Class IV - Dom/Rec

A cross involving four phenotypic categories has how many degrees of freedom on a chi-squared test?

• 1

• 2

• 3

• 4

Tags

NGSS.HS-LS3-3

NGSS.HS-LS4-3

A prevalent or baseline phenotype in a population is:

• wild-type

• normal

• mutant

• dominant

Tags

NGSS.HS-LS4-4

A dominant allele leads to a specific phenotype, but only 50% of individuals with this allele actually have the trait that is typically caused by this mutation. This is an example of:

• Expressivity

• Penetrance

• Gain-of-function

• Haploinsufficiency

A tall plant and a short plant are crossed and produce medium-height progeny. This is an example of:

• overdominance

• incomplete dominance

• heterozygote advantage

• codominance

There is an allele of a gene with a loss of function mutation. Heterozygote individuals have a phenotype This is:

• haploinsufficiency

• knockout

• recessive

• incomplete penetrance

We have a chi-squared value of 7.9 from a cross involving 4 phenotypes. Is this sufficient to reject the null hypothesis at a p-value cutoff of 0.01?

• Yes

• No

Creating a loss-of-function allele in the lab is referred to as:

• knockout

• blowout

• deletion

• CRISPR/Cas9

A mutation in a potassium channel now allows potassium ions to flow into and out of a cell without regulation. This mutation could be considered:

• haploinsufficient

• gain of function

• overdominance

• dominant negative

Polydactyly sometimes results in the addition of 1, 2, 3 or more digits. This is an example of?

• Incomplete penetrance

• Expressivity

• loss-of-function

• gain-of-function

A protein functions as part of a homodimer (protein that binds to another copy of the same protein). A mutation arises in this gene that disrupts the binding interactions that form the dimer, leading to a non-functioning protein complex. This mutation could be considered:

• gain of function

• haploinsufficient

• dominant negative

• overdominance

Tags

NGSS.HS-LS3-2