Unit 6: The Human Genome

In humans, the allele for having a cleft chin (C) is dominant over the allele for a smooth chin (c). One sister is homozygous dominant and the other sister is heterozygous. Which statement is true about the sisters?

• Both will have a smooth chin

• One will have a cleft chin and the other will have a smooth chin.

• Both will have a smooth chin and a cleft chin

• Both will have a cleft chin

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NGSS.HS-LS3-1

In rabbits, fur color is controlled by two alleles. The allele for brown fur is (B), and the allele for white fur is (b). A rabbit with the genotype Bb is crossed with a rabbit that is homozygous recessive (bb).

What percentage of the offspring is expected to have brown fur?

• 25%

• 50%

• 75%

• 100%

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NGSS.HS-LS3-1

NGSS.HS-LS3-3

In the Image: Which of the following statements best describes the inheritance of coat color in this species?

• Coat color is sex-linked because it is located on the X chromosome.
  

• All females will have black coats because they inherit two X chromosomes

• Males cannot have a black coat because they inherit only one X chromosome.

• The gene for coat color is located on the Y chromosome and affects only males.

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NGSS.HS-LS3-2

Hemophilia is a sex-linked recessive trait in humans caused by a gene located on the X chromosome. The allele for hemophilia is denoted as X^h, while the normal allele is X^H.

If a daughter is born with hemophilia, what is the probable genotypes of the parents?

• 
• 
• 
• 

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NGSS.HS-LS3-1

NGSS.HS-LS3-2

In humans, blood type is determined by the A, B, and O alleles. The A and B alleles are codominant, while the O allele is recessive. An individual with the AB genotype and an individual with the OO genotype can produce offspring with which of the following phenotypes?

• A, B, AB, or O
  

• A or B only

• AB only

• O only

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NGSS.HS-LS3-2

NGSS.HS-LS3-3

In humans, blood type is determined by the A, B, and O alleles. The A and B alleles are codominant to each other and dominant over the O allele. Could an individual with type O blood and an individual with type AB blood produce an offspring with type O blood?

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NGSS.HS-LS3-1

NGSS.HS-LS3-2

1. The pedigree below shows the inheritance pattern of a recessive allele (d) that results in a genetic disease.

Based on the inheritance pattern, what are the possible genotypes for individual 2?

• DD only

• Dd and DD

• dd

• Dd only

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NGSS.HS-LS3-1

NGSS.HS-LS3-2

A pedigree for the inheritance of an autosomal trait is shown here. What is the genotype of offspring B?

• AA only

• Aa only

• aa only

• AA and Aa

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NGSS.HS-LS3-1

NGSS.HS-LS3-2

Determine from the karyotype if the organism is genetically female or male.

• Female

• Male

• Unable to determine

Where is the mutation located?

• Autosomal Chromosome 2

• Autosomal Chromosome 16

• Autosomal Chromosome 21

• Sex Chromosomes

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NGSS.HS-LS3-1

NGSS.HS-LS3-2