AMS part I

1. Which antibiotic has good bioavailablity?

• Cefuroxime

• Erythromycin

• Cloxacillin

• Amoxicillin

1. Which antibiotic has poor bioavailability?

• Metronidazole

• Clindamycin

• Co-trimoxazole

• Azithromycin

1. Which antibiotic CANNOT be given simultaneously with multivalent cations found in dairy products?

• Metronidazole

• Ciprofloxacin

• Azithromycin

• Amoxicillin/clavulanic acid

1. Which of the following antibiotics is significantly affected by hypoalbuminemia & require dose adjustment?

• Cefazolin

• Ceftriaxone

• Meropenem

• Cefuroxime

1. Which of the following statement(s) is FALSE regarding dosing for antibiotic that are renally-excreted?

• Loading & maintenance doses should be determined based on the patient’s renal function

• Loading doses should not given to patients with renal impairment

• Maintenance doses should be adjusted in patients with renal impairment

• Unadjusted antibiotic doses may lead to accumulation & toxicity

• Antibiotics that are not renally excreted do not require renal dose adjustment

1. Which antibiotic is AUC-dependent?

• Levofloxacin

• Amikacin

• Cefepime

• Meropenem

1. Which antibiotic is time-dependent?

• Levofloxacin

• Amikacin

• Cefepime

• Vancomycin

1. Which statement is FALSE regarding Vancomycin?

• Enterococcus gallinarum is intrinsically resistant to Vancomycin

• Loading dose of 10-15mg/kg of IBW in severe MRSA infections

• Trough concentration is not a good surrogate marker of Vancomycin

• AUC₂₄/MIC of 400-600 is the target for serious infection caused by MRSA

1. Patient (male, 60 years old, 70 kg, SCr 240 umol/L) on IV Ceftazidime 2 g TDS for pseudomonas HAP. What is your comment?

• All good, no comment

• Should change to 1 g BD

• Should change to 1 g TDS

•   Should change to 2 g BD

1. Patient (80 kg) diagnosed with MRSA osteomyelitis. Dr decided to step down to oral antibiotic suppression therapy. What is your recommended regime for Co-trimoxazole tablet with the dose of 8 mg/kg TMP/day?

• 3 tab BD

• 4 tab BD

• 5 tab BD

• 2 tab BD