Cell Cycle Dynamics and Tumor Suppressor Mechanisms

This video tutorial covers the essentials of the cell cycle, focusing on its phases, regulation, and the role of proteins like cyclins, RB, and p53. It explains the importance of cell cycle checkpoints in preventing DNA mutations and cancer, and highlights the function of tumor suppressor genes in controlling cell division.

What are the two major phases of the cell cycle?

• Interphase and Cytokinesis

• Interphase and Mitosis

• Prophase and Metaphase

• Mitosis and Meiosis

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During which phase of mitosis do chromosomes align at the center of the cell?

• Prophase

• Telophase

• Anaphase

• Metaphase

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Which type of cell division results in genetically identical daughter cells?

• Budding

• Meiosis

• Mitosis

• Binary fission

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What is the primary function of the G1 phase in interphase?

• DNA replication

• Chromosome alignment

• Cell growth and preparation for DNA replication

• Cell division

Which phase of the cell cycle is known as the resting phase?

• G1

• S

• G2

• G0

What is the main purpose of cell cycle checkpoints?

• To synthesize proteins

• To ensure cell growth

• To repair DNA mutations

• To ensure proper cell division

Which protein is known as the 'guardian of the genome'?

• Cyclin

• p53

• RB

• CDK

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Which complex is primarily involved in the G1/S checkpoint?

• Cyclin A/CDK1

• Cyclin B/CDK2

• Cyclin E/CDK2

• Cyclin D/CDK4

What happens to RB protein when the appropriate signals for cell division are present?

• It forms a complex with p53

• It binds to DNA

• It is phosphorylated

• It is degraded

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What is the consequence of a mutation in the RB gene?

• Formation of non-functional proteins

• Inhibition of DNA replication

• Uncontrolled cell division

• Increased cell death

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