Therapeutics: DDIs

Atorvastatin, lovastatin, simvastatin

• CYP3A4

• CYP2C9

Answer explanation

Statins:

ALS=3A4

Rosuvastatin, fluvastatin, rosuvastatin

• CYP3A4

• CYP2C9

Answer explanation

Statins:

RFP = 2C9

ALS= 3A4

Which P2Y23i are we LESS concerned about DDIs?

• clopidogrel

• prasugrel

Answer explanation

Prasugrel is a minor substrate of CYPs. Even though it is a pro-drug, it is not concerning for DDIs

PLavix (clopidogrel) is a major substrate of ____

• CYP3A4

• CYP2C19

Nitrates are contraindicated in patients who use ____

• PDE5 i

• not this

Ranolazine is major substrate for ____

• CYP3A4

• CYP2C19

Cilostazol is a major substrate of ____ and ____

• CYP3A4

• CYP2C19

Major substrate of both CYP3A4 and CYP2C19.

• Ranolazine

• Cilostazol

Major substrate for only CYP3A4.

• Ranolazine

• Cilostazol

Select all of the CYP metabolized medications for CAD/PAD.

• statins

• clipidogrel and prasugrel

• nitrates

• ranolazine

• cilostazol