Lecture 11 B cell development

An anergic B cell can still bind to its complementary antigen.

• True

• False

Positive selection of B cells in secondary lymphatic tissues is dependent on the affinity of the immunoglobulin to its antigen.

• True

• False

Tags

NGSS.HS-LS4-4

If a patient is deficient in lambda 5, which of the following consequences are they likely to experience? (Select all that apply)

• cannot assemble the pre-B cell receptor

• are B cell immunodeficient

• cannot assemble the B cell receptor

• cells are consigned to die via apoptosis at the pro-B cell stage

The likelihood that a light chain rearrangement results in a productive rearrangement is higher than that of a heavy chain.

• True

• False

Tags

NGSS.HS-LS1-1

Negative selection (purging of self-reactive B cells) only takes place in the bone marrow.

• True

• False

The purging of self-reactive B cells in peripheral circulation can result in: (Select all that apply)

• anergy

• receptor editing

• apoptosis

• necrosis

A B cell whose heavy chain rearrangement is nonproductive can continue to rearrange that same locus for a new VDJ recombination.

• True

• False

___________ ensures that each B cells expresses a unique immunoglobulin.

• somatic recombination

• allelic exclusion

• somatic hypermutation