Chapter 6 Immuno

What is the first stage in the life cycle of B cells?

• Selection and further development

• Development in the bone marrow

• Activation in the lymph nodes

• Antibody production

Which stages are involved in the selection and further development of the B-cell repertoire?

• 1st, 2nd, and 3rd

• 2nd, 3rd, 4th, 5th, and 6th

• 1st, 4th, and 5th

• 3rd, 5th, and 6th

What occurs during the first stage of B lymphocyte development?

• Acquires functional B-cell receptors and Ig gene rearrangements

• Testing of Ig to normal constituents of the body

• Recirculation of mature B-cells

• Differentiation into plasma cells

What is the potential risk during the second stage of B lymphocyte development?

• Auto reactivity and autoimmune disease

• Loss of B-cell receptors

• Inability to mature

• Failure to differentiate

During which stage do immature B-cells become mature cells in secondary lymphoid tissues?

• 3rd stage

• 1st stage

• 5th stage

• 6th stage

Tags

NGSS.HS-LS1-4

What happens during the 5th stage of B lymphocyte development?

• Antigen contact leads to B cell progeny (clonal expansion)

• Testing of Ig to normal constituents

• Recirculation of mature B-cells

• Differentiation into plasma cells

What is the final stage in the development of B lymphocytes?

• Differentiation into plasma cells and long-lived memory B cells

• Recirculation of mature B-cells

• Testing of Ig to normal constituents

• Acquires functional B-cell receptors

Tags

NGSS.HS-LS1-4

What is the main focus of Phase 1 in the development of B cells?

• Negative selection

• Positive selection

• Repertoire assembly

• Attacking infection

During which phase does the alteration, elimination, or inactivation of B-cell receptors occur?

• Phase 1

• Phase 2

• Phase 4

• Phase 6

What happens in Phase 3 of B cell development?

• Recirculation of mature B cells

• Promotion of immature B cells to mature B cells

• Activation and clonal expansion

• Differentiation to plasma cells