IH 1 ABO SYSTEM

Who discovered the ABO blood group system?

• Von De Castello

• Sturli

• Hugo de Vries

• Karl Lansterner

What is the ABO locus located on?

• Chromosome 9

• Chromosome 15

• Chromosome 12

• Chromosome 7

What type of antibodies are present in the serum of people who lack the antigen?

• IgM

• IgA

• IgE

• IgG

What is the phenotype for an individual with genotype AO?

• A

• AB

• O

• B

What is the silent allele in the ABO system?

• H

• B

• A

• O

What is the Bombay phenotype characterized by?

• Absence of A and B antigens

• Presence of B antigen

• Absence of H substance

• Presence of A antigen

What does forward typing determine?

• Blood type compatibility

• Antigens on cells

• Presence of H substance

• Antibodies in serum

What is the role of the H gene?

• Produces O antigen

• Produces H substance

• Produces B antigen

• Produces A antigen

What happens if ABO antibodies react with antigens in vivo?

• Acute hemolysis and possibly death

• No reaction occurs

• Formation of new antigens

• Chronic hemolysis

What is the main advantage of monoclonal antibodies in ABO typing?

• Lower cost

• Stronger antibody strength

• Less risk of infection

• Easier to produce