Method Comparison Study in Clinical Laboratories

What is the primary purpose of performing a method comparison study in a clinical laboratory?

• To ensure the accuracy and reliability of a new method compared to an established reference method.

• To develop new testing sites.

• To create new statistical software.

• To eliminate the need for reference methods.

What is evaluated in a method comparison study?

• The relationship between test results using different methodologists or testing sites.

• The cost of new laboratory equipment.

• The number of tests performed in a day.

• The speed of data entry in laboratories.

Which software is mentioned for performing statistical analysis in a method comparison study?

• EP Evaluator

• SPSS

• MATLAB

• R Studio

What factors should be considered when interpreting the results of a method comparison study?

• Clinical significance, cost-effectiveness, ease of use, and limitations.

• The color of the laboratory equipment.

• The number of staff members.

• The location of the laboratory.

Which of the following is NOT applicable to the method comparison requirement?

• Calculated parameters (i.e. MCV, MCHC, MCH)

• Waived methods

• Laboratories with different CAP numbers

• Patient/client specimens

What type of specimens are preferred to avoid matrix effect in comparability studies?

• Calculated parameters

• Waived methods

• Pooled or non-pooled patient/client specimens

• Laboratories with different CAP numbers

What is the primary advantage of using pooled specimens in testing?

• It increases the accuracy of individual results.

• It allows for the detection of multiple pathogens simultaneously.

• It conserves resources and reduces costs.

• It eliminates the need for laboratory reagents.

How are non-pooled specimens processed?

• They are combined with other samples.

• They are tested separately and analyzed individually.

• They are only used for detecting viruses.

• They are discarded after initial testing.

What does the matrix of a specimen consist of?

• Only proteins and lipids.

• Various substances including proteins, lipids, and enzymes.

• Only exogenous compounds.

• Only medications and reagents.

What can the components of a specimen's matrix interact with?

• Only the specimen itself.

• The laboratory environment.

• Reagents or analytical methods used in the laboratory.

• The storage containers.