Macrocytic anemia

Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?

• EPO

• Transferrin

• Intrinsic factor

• Homocysteine

Evidence of a megaloblastic anemia includes:

• Microcytic RBCs

• Thrombocytosis

• Decreased red cell precursors with other cell lines unaffected

• Pancytopenia

All of the following are possible causes of low levels of intrinsic factor (IF) except :

• Gastrectomy

• Pernicious anemia

• Gastritis

• Kidney failure

Which MCV range is indicative of pernicious anemia?

• 70 -80

• 85 - 95

• 95-105

• 110-120

Which of the following RBC morphologies is classic in the megaloblastic anemias?

• Polychromasia

• Macro ovalocytes

• Macrocytes

• Hypochromia

A macrocytosis that is not megaloblastic in origin can be have all of the following except:

• Macrocytes

• Pancytopenia

• Decreased RBC count only

• Hypersegmentation

Which of the following describes the ineffective erythropoiesis seen with megaloblastic anemia?

• An increase in the M:E ratio

• A synthetic defect in hemoglobin

• Premature destruction of RBC precursors

• A DNA maturation defect

Intrinsic factor is secreted by the:

• Parietal cells

• Ileum

• Duodenum

• Bone marrow

The Schilling test continues to be a historic reference method for the determination of:

• IDA

• Pernicious anemia

• Folic acid deficiency

• Non megaloblastic anemia

Macrocytic RBCs are routinely seen in all of the following except:

• Pernicious anemia

• Liver disease

• Response to anemic stress

• Thalassemia