Blood Cell Formation and Development

The process of formation and development of blood cells is termed:

• Hematopoiesis

• Hematocrit

• Hematology

• Hematoma

During the second trimester of fetal development, the primary site of blood cell production is the:

• Bone marrow

• Spleen

• Lymph nodes

• Liver

Which one of the following organs is responsible for the maturation of T lymphocytes and regulation of their expression of CD4 and CD8?

• Spleen

• Thymus

• Liver

• Bone marrow

The best source of active bone marrow from a 20 year old would be:

• Femur

• Iliac crest

• Distal radius

• Tibia

Which organ is the site of sequestration of platelets?

• Bone marrow

• Liver

• Thymus

• Spleen

Which one of the following morphologic changes occurs during normal blood cell maturation?

• Condensation of nuclear chromatin

• Increase in cell diameter

• Development of cytoplasm basophilia

• Nuclear fragmentation

What is the primary function of erythrocytes?

• Hormone regulation

• Oxygen transport

• Immune response

• Blood clotting

What is the lifespan of a typical platelet?

• 100 days

• 40 days

• 7 days

• 10 days

Which one of the following cytokines is required very early

in the differentiation of a hematopoietic stem cell?

• IL-2

• IL-8

• EPO

• FLT3 ligand

When a patient has severe anemia and the bone marrow is

unable to effectively produce red blood cells to meet the

increased demand, one of the body’s responses is:

• Increased proportion of yellow marrow in the long

  bones

• Decreased production of erythropoietin by the kidney

• Extramedullary hematopoiesis in the liver and spleen

• Increased apoptosis of erythrocyte progenitor cells