Method

What is the primary purpose of method validation in analytical chemistry?

• To develop a new analytical instrument

• To confirm that an analytical method is suitable for its intended purpose

• To replace quality assurance procedures

• To minimize the cost of analysis

The ability of a method to distinguish and quantify the analyte in the presence of other components in the sample is referred to as __________.

Accuracy is determined by comparing the measured value to the true value of the analyte.

• True

• False

Which parameter evaluates the lowest concentration of an analyte that can be reliably detected but not necessarily quantified?

• Sensitivity

• Limit of Detection (LOD)

• Limit of Quantification (LOQ)

• Specificity

Recovery studies assess which of the following?

• The impact of small method changes on results

• The accuracy of the method in measuring spiked analytes

• The ability to quantify analytes at very low concentrations

• The correlation between analyte concentration and response

Which parameter measures the method's ability to provide proportional responses to analyte concentration?

• Sensitivity

• Linearity

• Specificity

• Accuracy

Which of the following is NOT a type of precision in method validation?

• Repeatability

• Intermediate precision

• Reproducibility

• Sensitivity