Connective/ Neural Tissue Lesions

Spindle-shaped cells that form into world patterns (circular)

• SARCOMATOUS LESIONS

• SOFT TISSUE LESIONS

• FIBROBLASTIC LESIONS

• - Torturous pattern

- Disorganized but spindle shaped - HPO

• SARCOMATOUS LESIONS

• SOFT TISSUE LESIONS

• FIBROBLASTIC LESIONS

Match the following:

• NEURAL LESION

• 
• SARCOMATOUS LESION

• 
• FIBROBLASTIC LESION

• 

If you remove the trauma/agent, it will revert back into its original phenotype.

• TRUE

• FALSE

• - Most common soft tissue sarcoma

- Range of spindle cell malignancies

(a)  

• - Considered now as a rare malignant spindle cell tumor without any connective tissue cell markers (IHIC)

• - Proliferation of malignant mesenchymal cells

(a)  

IHC: (+) S-100, (+) Neurafilament, indicates that the lesion is ___________ lesion?

• Neoplastic

• Neural

• Muscular

• Sarcomatous

All of these describe Fibrosarcoma, except

• Most common soft tissue sarcoma

• Range of spindle cell malignancies

• Considered now as a rare malignant spindle cell tumor without any connective tissue cell markers

• Exuberant connective tissue proliferation to a known stimulus or injury

= Aggressive and difficult to control

- 5-year survival rate: 30-50%

• Fibrosarcoma

• Solitary Fibrous Tumor

• Focal Fibrous Hyperplasia

• Hemangioma

What is the most common soft tissue sarcoma?

• Schwannoma

• Fibrosarcoma

• Neurofibroma

• Solitary fibrous tumor