Class V Dominance

Both alleles show a phenotype at same time (e.g., blood type)

• incomplete dominance

• codominance

• incomplete penetrance

• haploinsufficiency

Loss of function alleles are always recessive

• True

• False

Lab generated loss of function allele:

• blackout

• knockout

• punchout

• mutant

Tags

NGSS.HS-LS3-2

What is the typical "expected" phenotypic ratio in a chi-squared test of the results of an F2 dihybrid cross

• 9:3:3:1

• 9:7

• 3:1

• 1:2:1

Chi-squared value is 8.5 at 3 degrees of freedom. Is this sufficient to reject the null hypothesis at a p-value threshold of 0.01?

• Yes

• No

• Not enough information

• I quit

Heterozygotes for a loss-of-function mutation show a phenotype in:

• gain of function

• haploinsufficiency

• dominant negative

• knockout

Mutant allele antagonizes wildtype allele in:

• gain of function

• haploinsufficiency

• dominant negative

• knockout

A family has has extra fingers, but the number of fingers varies from 11 to 14 depending on the individual. This is an example of :

• incomplete penetrance

• expressivity

• incomplete dominance

• overdominance

Heterozygotes have an intermediate phenotype in:

• incomplete penetrance

• overdominance

• dominant negative

• incomplete dominance

50% penetrance refers to:

• 50% of individuals with genotype have phenotype

• phenotype is 50% severity

• 50% of population has phenotype

• 50% score on exam 1