DNA Replication
Quiz
•
Biology
•
9th - 12th Grade
•
Practice Problem
•
Medium
Standards-aligned
Zachary Ballard
Used 13K+ times
FREE Resource
About this resource
This quiz focuses on DNA replication, a fundamental molecular biology topic that forms the cornerstone of genetics and cellular biology education. The questions assess high school level understanding, specifically grades 9-12, covering both the conceptual framework and mechanistic details of how cells duplicate their genetic material. Students need a solid grasp of complementary base pairing rules (A-T and C-G), the antiparallel structure of DNA, and the sequential enzymatic processes that orchestrate replication. The quiz evaluates understanding of key enzymes including DNA helicase for unwinding the double helix, RNA primase for initiating synthesis, DNA polymerase for adding nucleotides, DNA ligase for joining fragments, and exonuclease for primer removal. Students must also comprehend the directional nature of DNA synthesis (5' to 3'), distinguish between leading and lagging strand synthesis, understand the formation of Okazaki fragments, identify replication fork structures, and recognize the semi-conservative nature of DNA replication where each new molecule contains one original and one newly synthesized strand. Created by Zachary Ballard, a Biology teacher in US who teaches grade 9-12. This assessment serves as an excellent tool for reinforcing the complex molecular processes that students encounter when studying cellular reproduction and heredity. The quiz works particularly well as a review activity following laboratory exercises or multimedia presentations on DNA structure and function, helping students consolidate their understanding before moving on to related topics like transcription and translation. Teachers can deploy this as a formative assessment to identify knowledge gaps, use it for homework to reinforce classroom learning, or incorporate it into warm-up activities to activate prior knowledge before deeper exploration of genetic concepts. The sequential enzyme questions make it especially valuable for students preparing for AP Biology or other advanced biology courses where detailed understanding of molecular mechanisms is essential. This quiz aligns with NGSS standards HS-LS1-1 (constructing models of molecules and cellular processes) and supports student achievement of performance expectations related to inheritance and variation of traits.
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17 questions
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1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
The picture below shows the steps of DNA replication beginning with step one and ending with step three.
Because you are reusing the old, or parent, DNA strand DNA replication is said to be
Semi- Conservative
Semi-discontinuous
Continuous
Fully-Conserveative
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
The picture below shows an enzyme unwinding and unzipping DNA.
What is the name of this enzyme?
DNA Helicase
DNA Ligase
DNA polyermase
RNA Polymerase
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Match he nucleotide with its complementary nucleotide. (DNA to DNA).
Adenine -
Thymine
Guanine
Cytosine
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Match he nucleotide with its complementary nucleotide. (DNA to DNA).
Cytosine-
Thymine
Guanine
Adenine
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which enzyme is responsible for adding the free nucleotides to the replicating DNA?
DNA Helicase
DNA Ligase
DNA polyermase
RNA Polymerase
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which is the first step?
DNA Helicase unwinds original DNA strand
RNA Primase lays down RNA primer for new nucleotide bases.
DNA polymerase builds new strands by bring in new nucleotide bases.
Ligase knits together fragments on lagging strand
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which is the second step?
DNA Helicase unwinds original DNA strand
RNA Primase lays down RNA primer for new nucleotide bases.
DNA polymerase builds new strands by bring in new nucleotide bases.
Ligase knits together fragments on lagging strand
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