Thalassemia PBL MCQs

Haemoglobin Barts syndrome is a type of abnormal haemoglobin that indicates genetic disorder called this Thalassemia

• Silent carrier

• Alpha thalassemia trait

• Haemoglobin H disease

• Hydrops Faetalis

• Beta thalassemia major.

Features of haemolytic anaemia include EXCEPT

• Increased Bilirubin

• Decreased haemopexin

• Increased reticulocyte count

• Increased urobilinogen

• Increased haptoglobin

Most complications of beta Thalassemia Major is due to

• Haemolysis of RBCs

• Increased bilirubin

• Plasma Iron overload

• Splenomegaly

• Extra medullary erythropoiesis

Splenomegaly, in beta thalassemia may lead to, EXCEPT

• Reduce the life span of of RBCs

• Susceptible to infection

• may cause low platelet, leads prolonged bleeding.

• Rupture. if enlarged too much.

• Increase the frequency of blood transfusion.

Bone marrow expands in chronic anaemia due to Beta-Thalassemia may lead to EXCEPT

• Compensates for lack of of RBCs

• Involved bones become thinner and brittle.

• Frontal head become prominent

• Affected bones may grow abnormally

• Decrease the iron overload for the synthesis of many RBC from the marrow

In beta thalassemia, the body compensates for low hemoglobin levels by increasing production of EXCEPT

• White blood cells

• Reticulocytes

• Red blood cells

• Platelets

• Hemoglobin F