Metabolism and Enzyme Deficiencies Quiz

The deficiency of glucose 6-phosphate dehydrogenase may cause

• diabetes mellitus

• hemolytic anemia

• Wernicke-Korsakoff syndrome

• all the above

Wernicke-Korsakoff syndrome may occur due to

• deficiency of G6PD

• defective transketolase

• defective glutathione peroxidase

• none of the above

All the following statements about HMP shunt are true except

• NADPH and pentoses are produced in the HMP shunt

• NADPH generated in the HMP shunt is utilised in steroid synthesis

• it occurs in the cytosol

• 12 ATP are generated in each pathway of HMP shunt

Glucose-6-phosphate dehydrogenase in erythrocytes are associated with maintaining

• the integrity of its membrane

• levels of reduced glutathione

• iron of hemoglobin in ferrous (Fe2+) state

• all the above

The persons with glucose-6-phosphate dehydrogenase deficiency are resistant to

• typhoid

• malaria

• tuberculosis

• none of the above

Uronic acid pathway is associated with the production of

• glucuronic acid

• pentoses

• vitamin C

• all the above

Humans cannot synthesise vitamin C due to the deficiency of the following enzyme

• UDP-glucose dehydrogenase

• glucuronidase

• L-gulonolactone oxidase

• xylitol dehydrogenase

Deficiency of the following enzyme causes hereditary fructose intolerance

• aldolase A

• aldolase B

• fructokinase

• glycerol kinase

The complications of severe uncontrolled diabetes mellitus are associated with the accumulation of the following molecule

• fructose

• glycerol

• sorbitol

• glyceraldehyde-3-phosphate

Fructose is the preferred source of energy to

• the brain

• adipose cells

• heart muscle

• sperms